MORPHOLOGICAL ANALYSIS OF METASTASES OF HEPAR WITH MR VOLUMETRY

Biljana Bozinovska; Biljana Prgova Veljanova; Violeta Hristova Janik; Masha Kostova; Dimitar Veljanovski; Andrea Nancheva Bogoevska; Ivona Jovanoska

Biljana Bozinovska City General Hospital 8mi September-Radiology Department in Skopje, North Macedonia
Biljana Prgova Veljanova City General Hospital 8mi September-Radiology Department in Skopje, North Macedonia
Violeta Hristova Janik General Hospital “Remedika” -Gastroenterohepatalogy Diseases Department in Skopje, North Macedonia
Masha Kostova City General Hospital 8mi September-Radiology Department in Skopje, North Macedonia
Dimitar Veljanovski City General Hospital 8mi September-Radiology Department in Skopje, North Macedonia
Andrea Nancheva Bogoevska City General Hospital 8mi September-Radiology Department in Skopje, North Macedonia
Ivona Jovanoska City General Hospital 8mi September-Radiology Department in Skopje, North Macedonia

Abstract

Increased frequency of incidence of metastatic liver disease has been noted especially among young women with breast cancer and young men with colorectal cancer. Metastatic liver deposits have a specific morphological appearance on MR . MR morphological imaging of metastases is based on proton spin of the hepatocytes, while the hepatic metastases have in a different sequence different display. On T1-sequence they are shown as focal hypo to isosignal round to oval irregular lesions of varying diameter sometimes with deeper central signal. The T2-sequence has a mixed signal depending on the type of vascularization, but specificity is obtained after intravenous application contrast, where metastases were shown with deep central signal but significant peripheral hypersignal in the form of a peripheral ring. Liver volumetry using magnetic resonance imaging (MRI) is method for quantitative measurement of the size and volume of the liver using MRI data. This is a non-invasive technique that provides important information about the anatomy of the liver and can help in the assessment of diseases and liver conditions, such as cirrhosis, liver tumors, metastases or fatty liver disease. In metastatic liver disease, hepatic volumetry as a method of calculating the residual the volume of the liver began to develop more and more with the development of the treatment of metastases, either surgical or oncological. The method represents a mathematical approach in date residual and responsible for the regenerative hepatic process, without affecting its function. Magnetic resonance imaging and volumetry are superior methods for diagnosis and treatment of metastases.

Keywords : MRI, Volumetry, Metastases, Liver.

References

1.Munemasa Ryu, Cho A (Eds). New Liver Anatomy: Portal Segmentation and the Drainage Vein. 2009th ed.
2.Hirano Y. Couinaud classification of hepatic segments. Last revised 16 Nov 2022.
3.Ronot M, Clift AK, Baum RP, Singh A, Kulkarni HR, Frilling A, Vilgrain V. Morphological and functional imaging for detecting and assessing the resectability of neuroendocrine liver metastases. Neuroendocrinology.
4.Sonnenschein C, Soto AM. Carcinogenesis and metastasis now in the third dimension—What’s in it for pathologists? Am J Pathol. 2006;168(2):409–11.
5.Fadaka A, Ajiboye B, Ojo O, Adewale O, Olayide I, Emuowhochere R. Biology of glucose metabolization in cancer cells. J Oncol Sci. [Open Access].
6.Kinkel K, Lu Y, Both M, Warren RS, Thoeni RF. Detection of hepatic metastases from GI cancers by US, CT, MRI, and PET: a meta-analysis. Radiology. 2002;224:748–56.
7.Fernandez FG, Drebin JA, Linehan DC, et al. Five-year survival after resection of hepatic metastases from colorectal cancer screened by FDG-PET. Ann Surg.
8.Bipat S, Van Leeuwen MS, Comans EF, et al. CT, MRI, and PET for diagnosis of colorectal liver metastases: meta-analysis. Radiology. 2005;237(1):123–31.
9.Sacks A, Peller PJ, Surasi DS, Chatburn L. Value of PET/CT in the management of liver metastases. AJR Am J Roentgenol. 2011.
10.Sasaki S, Ohtsuka T, Akimoto T. Prediction of post-hepatectomy liver failure using MRI-based volumetry and hepatocyte fraction. J Surg Oncol. 2021.
11.Ward J. New MR techniques for the detection of liver metastases. Cancer Imaging. 2006.
12.Yu JS, Rofsky NM. Hepatic metastases: perilesional enhancement on dynamic MRI. AJR Am J Roentgenol. 2006;186:1051–8.
13.Kim TK, Jang HJ, Burns PN. Diagnosis of liver metastasis: value of contrast-enhanced US vs. contrast-enhanced CT and MRI. Radiology. 2011.
14.Kierans AS, Kuo YC, Hahn PF, et al. Detection of liver metastases: comparison of CE-CT, CE-US, SPIO-MRI, and gadoxetate MRI. J Comput Assist Tomogr. 2011.
15.Valls C, Gumà A, Puig I, et al. Hepatic metastases: interobserver agreement and diagnostic accuracy of hepatobiliary phase MRI. Radiology. 2002.
16.Paulatto L, Dioguardi Burgio M, Sartoris R, et al. Colorectal liver metastases: radiopathological correlation. Insights Imaging. 2020.
17.Semelka RC, Hussain SM, Marcos HB, Woosley JT. Perilesional enhancement of hepatic metastases: MR and histopathology. Radiology. 2000.
18.Lee VS, Lavelle MT, Rofsky NM, et al. Hepatic MRI with DCE isotropic VIBE: feasibility and technical quality. Radiology. 2000.
19.Ward J, Robinson PJ, Guthrie JA, et al. Detection of liver metastases: CT, 3D gadolinium MRI, and SPIO-enhanced imaging. Radiology. 2005.
20.Gultekin MA, Turk HM, Yurtsever I, et al. ADC values for neuroendocrine liver metastases.
21.Karaosmanoglu AD, et al. MRI of liver metastasis. Semin Ultrasound CT MR. 2016.
22.Dromain C, et al. MR imaging of hepatic neuroendocrine metastases: technique comparison. AJR Am J Roentgenol. 2003.
23.d'Assignies G, et al. High sensitivity of DWI MRI for neuroendocrine liver metastases. Radiology. 2013.
24.Carlbom L, et al. Whole-body DWI MRI vs. 5-HTP PET/CT for neuroendocrine tumor detection. Upsala J Med Sci. 2017.
25.Caudana R, Morana G, Pirovano GP, et al. MR imaging with gadolinium BOPTA for hepatic lesions. Radiology. 1996;199:513–20.
26.Reimer P, Rummeny EJ, Daldrup HE, et al. Enhancement patterns with Gd-EOB-DTPA. Eur Radiol. 1997;7:275–80.
27.Lewis JR, Do RK, Kirsch JS. MRI volumetry of hepatic metastases. AJR Am J Roentgenol. 2017.
28.Healey M, Pring J, Metcalfe T. MRI liver volumetry to predict post-op liver volume. Eur Radiol. 2018.
29.Yoon S, Lee JS, Lee JH. MRI liver volumetry vs. intraoperative liver volume estimation. Abdom Radiol. 2018.
30.Pech J, Sutterlin K, Kraus T. Liver volume changes post-chemotherapy in colorectal liver metastases. J Gastrointest Surg. 2019.
31.Ohtsuka T, Takahashi K, Akimoto T. Liver volume as predictor of post-hepatectomy failure. Surg Today. 2020.
32.Sasaki S, Ohtsuka T, Akimoto T. MRI liver volumetry for predicting liver failure. J Surg Oncol. 2021.
33.Hardie AD, Naik M, Hecht EM, Chandarana H. DWI MRI vs. gadolinium-enhanced for liver metastases. PubMed. 2010.
34.Seneterre E, Taourel P, Bouvier Y, et al. Ferumoxides-enhanced MRI vs. CT for hepatic metastases. Radiology. 1996;200:785–92.
35.D’Souza MM, Sharma R, Mondal A, et al. CECT vs. FDG-PET/CT in detecting hepatic metastases. Nucl Med Commun. 2009;30(2):117–25.
36.Renzulli M, Clemente A, Ierardi AM, et al. Imaging of colorectal liver metastases: updates. Cancers. 2020;12(1):151.
37.Pech J, Sutterlin K, Kraus T. Liver volume changes post-chemotherapy in colorectal liver metastases. J Gastrointest Surg. 2019.
38.Ohtsuka T, Takahashi K, Akimoto T. Liver volume as predictor of post-hepatectomy failure. Surg Today. 2020.
39.Fernandez FG, Drebin JA, Linehan DC, et al. Five-year survival after hepatic metastasis resection using FDG-PET screening. Ann Surg. 2004.
40.Paulatto L, Dioguardi Burgio M, Sartoris R, et al. Colorectal liver metastases: radiopathological correlation. Insights Imaging. 2020.
41.Semelka RC, Hussain SM, Marcos HB, Woosley JT. Perilesional enhancement in hepatic metastases. Radiology. 2000.
42.Lee VS, Lavelle MT, Rofsky NM, et al. Hepatic MR imaging with isotropic VIBE. Radiology. 2000.
43.Ward J, Robinson PJ, Guthrie JA, et al. CT vs. 3D gadolinium and SPIO-enhanced MRI for metastasis detection. Radiology. 2005.
44.Gultekin MA, Turk HM, Yurtsever I, et al. ADC values for neuroendocrine liver metastases.
45.Karaosmanoglu AD, et al. MRI of liver metastasis. Semin Ultrasound CT MR. 2016.
46.Dromain C, et al. MR imaging of neuroendocrine liver metastases: comparison of methods. AJR Am J Roentgenol. 2003.
47.d'Assignies G, et al. DWI MRI vs. other MR techniques for detecting neuroendocrine metastases. Radiology. 2013.
48.Carlbom L, et al. WB-MRI with DWI vs. 5-HTP PET/CT in neuroendocrine tumors. Upsala J Med Sci. 2017.
49.Caudana R, Morana G, Pirovano GP, et al. Gadolinium BOPTA-enhanced MRI for liver lesions. Radiology. 1996;199:513–20.
50.Yoon S, Lee JS, Lee JH. MRI-based liver volumetry vs. intraoperative estimates. Abdom Radiol. 2018.
51.Lewis JR, Do RK, Kirsch JS. MRI volumetry in evaluation of liver metastases. AJR Am J Roentgenol. 2017.
52.Healey M, Pring J, Metcalfe T. Predicting liver volume post-hepatectomy using MRI. Eur Radiol. 2018.