• Pavle Gjorgjievski Department of Oral Surgery , Goce Delcev University in Stip, North Macedonia
  • Kiro Papakoca Faculty of Medical Sciences, Goce Delcev University in Stip, North Macedonia
  • Mirjana Markovska Arsovska Faculty of Medical Sciences `Goce Delcev University in Stip, North Macedonia
  • Cena Dimova Faculty of Medical Sciences, Goce Delcev University in Stip, North Macedonia
  • Simona Temelkova PZU``Dr. Snezana Temelkova``, North Macedonia
  • Elizabeta Chadikovska Institute of Anatomy, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia


Guided bone regeneration (GBR) is a bone graft procedure that uses a covering barrier membrane to block soft tissue invasion. Bone reconstruction for implant placement and for preparation for prosthetic restorations  varies in numerous techniques and materials, each of them bringing advantages and specific qualities for different types of bone defects. The case report present an efficient method of GBR by sticky bone which is obtained by mixing PRF and bone graft together supported by PRF membrane. During the regular controls, no big swelling was seen, the patient did not complain of pain. The postoperative course was without complications.

Keywords: PRF, guided bone regeneration, bone defect, sticky bone, PRF membrane


1. Moussa NT, Dym H. Maxillofacial Bone Grafting Materials. Dent Clin North Am. 2020 Apr;64(2):473-490.
2. Chiapasco M, Casentini P. Horizontal bone-augmentation procedures in implant dentistry: prosthetically guided regeneration. Periodontology 2000. 2018; 77(1), 213–240; doi: 10.1111/prd.12219. 3. Zhao R, Yang R, Cooper PR, Khurshid Z, et al. Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments. Molecules. 2021 May 18;26(10):3007.
4. Kim HS, Kim YK, Yun PY. Minimal invasive horizontal ridge augmentation using subperiosteal tunneling technique. Maxillofac Plast Reconstr Surg. 2016;38(1):41.
5. Deeb GR, Wilson GH, Carrico CK, Zafar U, et al. Is the Tunnel Technique More Effective Than Open. Augmentation With a Titanium-Reinforced Polytetrafluoroethylene Membrane for Horizontal Ridge Augmentation? Journal of Oral and Maxillofacial Surgery. 2016; 74(9):1752–1756.
6.Pavlovic V et al. Platelet-rich fibrin: Basics of biological actions and protocol modifications. Open medicine v.16(1); 2021.
7.Cortese A, Pantaleo G, Amato M, Howard CM, Pedicini L, Claudio PP. Platelet-rich fibrin (PRF) in implants dentistry in combination with new bone regenerative flapless technique: Evolution of the technique and final results. Open Med (Wars) 2017;12:24–3.
8. Soni R, Singh A, Vivek R, Baranwal HC, Chaturvedi TP, Srivastava A. Immediate implant placement in mandibular anterior region with dehiscence. J Dent Implant. 2013;3:177–80.
9. Meloni SM, De Riu G, Pisano M, Dell’aversana Orabona G, Piombino P, Salzano G, et al. Computer-assisted implant surgery and immediate loading in edentulous ridges with dental fresh extraction sockets. Two years results of a prospective case series study. Eur Rev Med Pharmacol Sci. 2013;17:2968–73.
10. Sammartino G, Pantaleo G, Nuzzolo P, Amato M, Riccitiello F. Minimally invasive approaches to optimize block grafting: A case report. J Oral Implantol. 2016;42:176–9.
11. Cortese A, Pantaleo G, Borri A, Caggiano M, Amato M. Platelet-rich fibrin (PRF) in implant dentistry in combination with new bone regenerative technique in elderly patients. Int J Surg Case Rep. 2016;28:52–6.
12. Wang HL, Boyapati L. "PASS" principles for predictable bone regeneration. Implant Dent. 2006;15:8–17.
13. Mestas G, Alarcón M, Chambrone L. Long-term survival rates of titanium implants placed in expanded alveolar ridges using split crest procedures: A systematic review. Int J Oral Maxillofac Implants. 2016;31:591–9.
14. Waechter J, Leite FR, Nascimento GG, Carmo Filho LC, Faot F. The split crest technique and dental implants: A systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2017;46:116–28.
15.Gielkens PF, Bos RR, Raghoebar GM, Stegenga B. Is there evidence that barrier membranes prevent bone resorption in autologous bone grafts during the healing period? A systematic review. Int J Oral Maxillofac Implants. 2007;22:390–8.
How to Cite
GJORGJIEVSKI, Pavle et al. GUIDED BONE REGENERATION IN RECONSTRUCTION OF BONE DEFECTS. Journal of Morphological Sciences, [S.l.], v. 7, n. 1, p. 198-201, may 2024. ISSN 2545-4706. Available at: <>. Date accessed: 20 june 2024.
Case Report