ANNUAL CHANGE OF ESTIMATED GLOMERULAR FILTRATION RATE IN HEALTHY INDIVIDUALS

Stefan Filipovski; Vlatko Karanfilovski; Angela Karanfilovikj; Panche Nikolov; Blerim Bedzheti; Zaklina Sterjova; Nikola Gjorgjievski; Zoran Janevski; Irena Rambabova Busletikj; Lada Trajceska; Goce Spasovski

Stefan Filipovski University Clinic of Nephrology, Faculty of Medicine, University Ss. Cyril and Methodius, Skopje, North Macedonia
Vlatko Karanfilovski University Clinic of Nephrology, Faculty of Medicine, University Ss. Cyril and Methodius, Skopje, North Macedonia
Angela Karanfilovikj University Clinic of Nephrology, Faculty of Medicine, University Ss. Cyril and Methodius, Skopje, North Macedonia
Panche Nikolov Public Health Institution, Health Facility, Radovish, North Macedonia
Blerim Bedzheti University Clinic of Nephrology, Faculty of Medicine, University Ss. Cyril and Methodius, Skopje, North Macedonia
Zaklina Sterjova University Clinic of Nephrology, Faculty of Medicine, University Ss. Cyril and Methodius, Skopje, North Macedonia
Nikola Gjorgjievski University Clinic of Nephrology, Faculty of Medicine, University Ss. Cyril and Methodius, Skopje, North Macedonia
Zoran Janevski University Clinic of Nephrology, Faculty of Medicine, University Ss. Cyril and Methodius, Skopje, North Macedonia
Irena Rambabova Busletikj University Clinic of Nephrology, Faculty of Medicine, University Ss. Cyril and Methodius, Skopje, North Macedonia
Lada Trajceska University Clinic of Nephrology, Faculty of Medicine, University Ss. Cyril and Methodius, Skopje, North Macedonia
Goce Spasovski University Clinic of Nephrology, Faculty of Medicine, University Ss. Cyril and Methodius, Skopje, North Macedonia

Abstract

Physiologically, GFR level should be stable up to the end of the fifth decade of life. When measured more frequently, wide dispersion of GFR results have been seen, but, after 5^th decade GFR is expected to reduce by 1ml/min/1,73m2 yearly. The aim of this study was to calculate the change of estimated GFR on annual level and its correlations in healthy individuals. This was a retrospective observational study on 62 healthy subjects during 6 years. Demographical characteristics as gender, age, BMI, obesity (defined as BMI above 30kg/m²) and annual creatinine were obtained from medical files at the general practitioner. Serum creatinine level was measured at one biochemical laboratory. eGFR was calculated with CKD EPI formula. Calculation of the mean annual GFR change (Î´GFR) was done through the method of data smoothing. Statistics: Continuous variables are shown as average and standard deviation and the nominal ones with number and percent. GFR change was correlated with age and BMI. Comparative analyses of Î´GFR in relation to gender and obesity was done by non-parametric Mann-Whiney U test. P was considered significant if less than 0.05. Mean age of the study group was 39.5 years, dominantly male (78%). Mean BMI was 26,3 Â± 3.81 kg/m², 13% were obese. The mean annual GFR fluctuated (101.8 Â± 5.56; 108.0 Â± 31.04; 102.8 Â± 18.28;103.2 Â± 20.49; 99.10 Â± 24.28; 103.55 Â± 20.74 mL/min/1.73m², respectively). The Î´GFR median value was 2.3 mL/min/1.73m² with range of -23 to +20, and its correlations with age and BMI were insignificant (r= -0.058, p=0.681, r= 0.128, p=0.111, respectively). The Î´GFR did not differ significantly between genders and obese vs nonobese subjects (p=0.577; p=0.768, respectively). This study demonstrated that annual GFR change wasnâ€™t correlated to age, gender and BMI. It also elucidated the fact of a high variable eGFR levels and its annual decline in presumed healthy persons. This fact emphasizes the need for thorough evaluation of the candidates for kidney donors, especially when applying the expanded criteria.

Key words: GFR, healthy subjects, kidney function decline, donors.

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