BIOFILM IN CHRONIC DIABETIC FOOT ULCER-CASE REPORT

  • Julija Mitrova Telenta University Clinic of Dermatology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Liljana Labacevska Gjatovska Institut of Microbiology and Parasitology, Faculty of Medicine, Ss.Cyril and Methodius University in Skopje, North Macedonia
  • Marko Kostovski Institut of Microbiology and Parasitology, Faculty of Medicine, Ss.Cyril and Methodius University in Skopje, North Macedonia
  • Maja Dimova University Clinic of Dermatology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Ivana Dohceva Karajovanov University Clinic of Dermatology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Suzana Nikolovska University Clinic of Dermatology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Silvija Duma University Clinic of Dermatology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Hristina Breshkovska University Clinic of Dermatology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Nikola Panovski Institut of Microbiology and Parasitology, Faculty of Medicine, Ss.Cyril and Methodius University in Skopje, North Macedonia

Abstract

Diabetic foot ulcers(DFUs) as one of the most common complications in patients with diabetes mellitus are usually chronic wounds.The reason for its chronicity are infections and biofilm formation. We present a patient with diabetic foot neuropathic ulcer on the right foot. Microbiological swab showed isolates of  bacteria and fungi, Candida albicans,Enterococcus and Acinetobacter which were tested for biofilm formation with microtiter plate assay. Biofilm mass was evaluated spectrophotometrically by measuring the absorbence of crystal violet. Enterococcus was with high potential of biofilm formation. Wound surface was measured every week for a period of one month and it was reduced for 23.93%. Ulcer was treated with peroral antibiotic and antifungal medications and standard wound care was performed. Microorganisms isolated from wound swabs showed mixed bacterial and fungal components. Current sudies show that relation in between this biofilm is still unclear. All of this is a key role in treating chronic wounds, making it a challenge for everyone not only in the field of making  diagnosis , but also in the field of treatment.


 Key words: diabetic foot ulcers(DFUs),bacteria, fungi, biofilm


 

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Published
2023-12-27
How to Cite
TELENTA, Julija Mitrova et al. BIOFILM IN CHRONIC DIABETIC FOOT ULCER-CASE REPORT. Journal of Morphological Sciences, [S.l.], v. 6, n. 3, p. 246-250, dec. 2023. ISSN 2545-4706. Available at: <https://jms.mk/jms/article/view/vol6no3-31>. Date accessed: 27 july 2024.
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