THE INFLUENCE OF ACUTE DECOMPENSATION ON ONE-YEAR SURVIVAL AND MORTALITY IN PATIENTS WITH LIVER CIRRHOSIS

  • Elena Curakova Ristovska University Clinic for Gastroenterohepathology, Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Magdalena Genadieva-Dimitrova University Clinic for Gastroenterohepathology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Beti Todorovska University Clinic for Gastroenterohepathology, Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Kalina Grivceva Stardelova University Clinic for Gastroenterohepathology, Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Ivan Rankovich Department of Gastroenterology, Royal Cornwall Hospitals National Health Services (NHS) trust, England, UK
  • Vladimir Milivojevich Medcompass Alliance, Belgrade, Serbia; School of Medicine, Belgrade University, Belgrade, Serbia
  • Ante Bogut University Hospital Mostar, Department of Gastroenterology Mostar, Bosnia and Hrezegovina, School of Medicine University of Mostar, Mostar, Bosnia and Herzegovina
  • Georgi Janevski University Clinic for Gastroenterohepathology, Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia

Abstract

Acute decompensation (AD) disposes important prognostic potential in cirrhotic patients, but the relation with the significant mortality predictors has not been fully investigated. We aimed to evaluate the influence of AD on the independent predictors of one-year mortality.  In 71 cirrhotic patients we analyzed the relation between AD and prognostic scores and indicators. We evaluated the independent association between several variables and one-year survival and their independent prognostic value for one-year mortality, before and after adjustment with the AD status.  AD patients (32) had significantly higher values of CTP, MELD, SOFA, and SAPS II scores, C-reactive protein (CRP), ferritin, leukocyte count, bilirubin, prothrombin time, INR, von-Willebrand factor and D-dimer concentration and lower values of vitamin D, hemoglobin, albumin, and sodium. MELD score (p=0.047), CRP (p=0.001), and vitamin D (p=0.014) were independently associated with one-year survival, while MELD score (p=0.010) and CRP (p=0.036) were independent predictors of one-year mortality. After adjustment with AD, MELD score was no longer independently associated with one-year survival and MELD score and CRP were no longer independent predictors of one-year mortality. AD has a strong influence on the variables independently associated with one-year survival and on the independent predictors of one-year mortality.

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Published
2023-12-26
How to Cite
CURAKOVA RISTOVSKA, Elena et al. THE INFLUENCE OF ACUTE DECOMPENSATION ON ONE-YEAR SURVIVAL AND MORTALITY IN PATIENTS WITH LIVER CIRRHOSIS. Journal of Morphological Sciences, [S.l.], v. 6, n. 3, p. 10-20, dec. 2023. ISSN 2545-4706. Available at: <https://jms.mk/jms/article/view/vol6no3-3>. Date accessed: 21 dec. 2024.
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