BILATERAL CONGENITAL CATARACT IN A NEWBORN- LITERATURE REVIEW AND CASE REPORT

  • Igor Isjanovski PHI University Clinic for Eye Diseases, Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, North Macedonia
  • Stefan Pandilov PHI University Clinic for Eye Diseases, Skopje, North Macedonia
  • Emilija Gjosevska Dashtevska PHI University Clinic for Eye Diseases, Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, North Macedonia

Abstract

Congenital cataract is the leading cause of childhood blindness. The etiology for its occurrence can be different: metabolic diseases, genetic factors, infectious agents, but mostly idiopathic. The purpose of this paper is to present a case of congenital cataract in a 10-day-old infant who presented with leukocoria in the first days of life, as well as to provide an overview of modern diagnostic and therapeutic modalities in the management of this ophthalmic condition. In the preparation of this topic, medically relevant data obtained from three large databases were used: PubMed, Embase and Scopus. Keywords such as: congenital cataract, newborn, leukocoria, red reflex were used during the search. The obtained data were selected and processed, while the latest and most relevant knowledge from this field was included in the preparation of this paper. Rapid recognition of this condition is important in order to preserve good visual function and avoid the potential complications of its presence: deprivation amblyopia, strabismus, nystagmus and glaucoma.


 Keywords: congenital cataract, leukocoria, red reflex, newborn.

References

1. Foster A, Gilbert C, Rahi J. Epidemiology of cataract in childhood: a global perspective. J Cataract Refract Surg. 1997;23 Suppl 1:601-4.
2. Katre D, Selukar K. The Prevalence of Cataract in Children. Cureus. 2022 Oct 10;14(10):e30135.
3. Childhood cataract: magnitude, management, economics and impact. Community Eye Health. 2004;17(50):17-8.
4. Khokhar SK, Pillay G, Agarwal E, Mahabir M. Innovations in pediatric cataract surgery. Indian J Ophthalmol. 2017 Mar;65(3):210-216.
5. Cvekl A, Duncan MK. Genetic and epigenetic mechanisms of gene regulation during lens development. Prog Retin Eye Res. 2007 Nov;26(6):555-97.
6. Pichi F, Lembo A, Serafino M, Nucci P. Genetics of Congenital Cataract. Dev Ophthalmol. 2016;57:1-14.
7. Haargaard B, Fledelius HC. Down's syndrome and early cataract. Br J Ophthalmol. 2006 Aug;90(8):1024-7.
8. Cassidy L, Taylor D. Congenital cataract and multisystem disorders. Eye (Lond). 1999 Jun;13 ( Pt 3b):464-73.
9. Xu JM, Zhang SS, Zhang Q, Zhou YM, Zhu CH, Ge J, Wang L. Ocular manifestations of Alport syndrome. Int J Ophthalmol. 2010;3(2):149-51.
10. Stambolian D. Galactose and cataract. Surv Ophthalmol. 1988 Mar-Apr;32(5):333-49.
11. Janzen N, Illsinger S, Meyer U, Shin YS, Sander J, Lücke T, Das AM. Early cataract formation due to galactokinase deficiency: impact of newborn screening. Arch Med Res. 2011 Oct;42(7):608-12.
12. Chacon Fonseca I, Wong J, Mireskandari K, Chitayat D. Newborn with bilateral congenital cataracts: Never forget congenital rubella syndrome. Paediatr Child Health. 2020 Mar;25(2):72-76.
13. Lu B, Yang Y. Detection of TORCH pathogens in children with congenital cataracts. Exp Ther Med. 2016 Aug;12(2):1159-1164.
14. Gurnani B, Kaur K. Posterior Polar Cataract. 2023 Jun 11. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–.
15. Hwang SS, Kim WS, Lee SJ. Clinical features of strabismus and nystagmus in bilateral congenital cataracts. Int J Ophthalmol. 2018 May 18;11(5):813-817.
16. Thompson DA, Møller H, Russell-Eggitt I, Kriss A. Visual acuity in unilateral cataract. Br J Ophthalmol. 1996 Sep;80(9):794-8.
17. Kanukollu VM, Tripathy K. Leukocoria. 2023 Feb 22. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–.
18. Birch EE, Stager DR. The critical period for surgical treatment of dense congenital unilateral cataract. Invest Ophthalmol Vis Sci. 1996 Jul;37(8):1532-8.
19. Lambert SR, Lynn MJ, Reeves R, Plager DA, Buckley EG, Wilson ME. Is there a latent period for the surgical treatment of children with dense bilateral congenital cataracts? J AAPOS. 2006 Feb;10(1):30-6.
20. Bremond-Gignac D, Daruich A, Robert MP, Valleix S. Recent developments in the management of congenital cataract. Ann Transl Med. 2020 Nov;8(22):1545.
21. Infant Aphakia Treatment Study Group; Lambert SR, Lynn MJ, Hartmann EE, DuBois L, Drews-Botsch C, Freedman SF, Plager DA, Buckley EG, Wilson ME. Comparison of contact lens and intraocular lens correction of monocular aphakia during infancy: a randomized clinical trial of HOTV optotype acuity at age 4.5 years and clinical findings at age 5 years. JAMA Ophthalmol. 2014 Jun;132(6):676-82.
22. Morrison DG, Wilson ME, Trivedi RH, Lambert SR, Lynn MJ; Infant Aphakia Treatment Study Group. Infant Aphakia Treatment Study: effects of persistent fetal vasculature on outcome at 1 year of age. J AAPOS. 2011 Oct;15(5):427-31.
23. Chen J, Chen Y, Zhong Y, Li J. Comparison of visual acuity and complications between primary IOL implantation and aphakia in patients with congenital cataract younger than 2 years: a meta-analysis. J Cataract Refract Surg. 2020 Mar;46(3):465-473.
24. Chan WH, Biswas S, Ashworth JL, Lloyd IC. Congenital and infantile cataract: aetiology and management. Eur J Pediatr. 2012 Apr;171(4):625-30.
25. Geyer O, Segal A, Melamud A, Wolf A. Clinical Outcomes After Ahmed Glaucoma Valve Implantation for Pediatric Glaucoma After Congenital Cataract Surgery. J Glaucoma. 2021 Jan 1;30.
Published
2023-12-27
How to Cite
ISJANOVSKI, Igor; PANDILOV, Stefan; DASHTEVSKA, Emilija Gjosevska. BILATERAL CONGENITAL CATARACT IN A NEWBORN- LITERATURE REVIEW AND CASE REPORT. Journal of Morphological Sciences, [S.l.], v. 6, n. 3, p. 170-175, dec. 2023. ISSN 2545-4706. Available at: <https://jms.mk/jms/article/view/vol6no3-22>. Date accessed: 22 oct. 2024.
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Articles