BIODISTRIBUTION STUDY OF 188Re-HEDP AS A RADIOPHARMACEUTICAL FOR BONE PAIN PALLIATION

  • Toni Tripunoski Institute of Pathophysiology and Nuclear Medicine, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Domokos Mathe Frederic Joliot-Curie National Institute of Radiobiology and Radiohygiene, Dept. of Applied Radioisotopes, Budapest, Hungary
  • Lajos Balog Frederic Joliot-Curie National Institute of Radiobiology and Radiohygiene, Dept. of Applied Radioisotopes, Budapest, Hungary
  • Ana Ugrinska Department of Radioisotopes and Radiopharmaceuticals Production, University Institute of Positron Emission Tomography, Skopje, North Macedonia
  • Maja Chochevska Department of Radioisotopes and Radiopharmaceuticals Production, University Institute of Positron Emission Tomography, Skopje, North Macedonia
  • Sinisa Stojanoski Institute of Pathophysiology and Nuclear Medicine, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Nikolina Bozinovska Institute of Pathophysiology and Nuclear Medicine, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Nevena Manevska Institute of Pathophysiology and Nuclear Medicine, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Anamarija Jankulovska Institute of Pathophysiology and Nuclear Medicine, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Daniela Popgjorceva Institute of Pathophysiology and Nuclear Medicine, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia

Abstract

Bone seeking radiopharmaceuticals like Rhenium-188 hydroxy ethylidene diphosphonate (188Re-HEDP) are used for palliative treatment of bone metastases, and as target radionuclide therapy in patients with inoperable osteosarcoma in addition to the external radiation therapy. In this study was evaluated the preparation, quality control and biodistribution of 188Re-HEDP in mice to be determined the in vivo affinity to the target bone tissue and to the other non-target tissues and organs. 188Re-HEDP was prepared with radiochemical purity of 98.87%. Its biodistribution data showed high uptake and durability in the skeletal tissues without significant uptake in other tissues and organs. It means that 188Re-HEDP kit formulation and the prescribed conditions in our study allows obtaining a radiopharmaceutical with promising therapeutic efficiency in palliative treatment of primary bone tumors as well as secondary osseous metastatic lesions.


Keywords: bone pain palliation, radionuclide therapy, radiopharmaceuticals, Rhenium-188

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Published
2023-12-27
How to Cite
TRIPUNOSKI, Toni et al. BIODISTRIBUTION STUDY OF 188Re-HEDP AS A RADIOPHARMACEUTICAL FOR BONE PAIN PALLIATION. Journal of Morphological Sciences, [S.l.], v. 6, n. 3, p. 78-84, dec. 2023. ISSN 2545-4706. Available at: <https://jms.mk/jms/article/view/vol6no3-11>. Date accessed: 02 mar. 2024.
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