THE ROLE OF T2W PULSE SEQUENCE AND DIFFUSION WITH ITS NUMERICAL ADC MAP IN PROSTATE CANCER DIAGNOSIS

Masha Kostova; Elizabeta Stojovska Jovanovska; Ace Dodevski; Dimitar Veljanovski; Sandra Dejanova Panev; Biljana Prgova Veljanova

Masha Kostova Department of Radiology, City General Hospital â€œ8th Septemberâ€, Skopje, North Macedonia
Elizabeta Stojovska Jovanovska University Institute of Radiology, Skopje. Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
Ace Dodevski Institute of Anatomy, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
Dimitar Veljanovski Department of Radiology, City General Hospital â€œ8th Septemberâ€, Skopje, Faculty of Medicine, Ss Cyril and Methodius Univerity in Skopje, North Macedonia
Sandra Dejanova Panev Department of Radiology, City General Hospital â€œ8th Septemberâ€, Skopje, Faculty of Medicine, Ss Cyril and Methodius Univerity in Skopje, North Macedonia
Biljana Prgova Veljanova 1Department of Radiology, City General Hospital â€œ8th Septemberâ€, Skopje, Faculty of Medicine, Ss Cyril and Methodius Univerity in Skopje, North Macedonia

Abstract

In patients with increased PSA (prostate-specific antigen), the next diagnostics tool is transrectal ultrasound-guided biopsy-TRUS. Multiparametric magnetic resonance imaging (mp MRI) as non invasive diagnostic tool is used as a triage test to avoid biopsy, as well as to improve the diagnostics. In our study we want to prove the clinical meaning of T2W pulse sequence and diffusion as a part of mp MRI in prostate malignant lesions detection and their distinction from the benign lesions. This cohort prospective study included 100 patients with increased levels of PSA from 4 ng/ml to 76 ng/ml. The MRI equipment used was Siemens Essenza1,5T with body coil. The results from the T2W pulse sequence and diffusion are correlated with the values of diffusion and ADC map, in which the suspected zones are marked on a template. Patients undergo biopsy depending on the PIRADS (prostate-imaging and reporting data system) classification. The MRI results and the pathohistological findings are then compared. Clinically significant cancer is considered to be a cancer with a Gleason score 6, diameter > 6mm. The values of diffusion with its numerical ADC map are considerably lower for malignant nodules compared to benign ones. Hyposignal of T2W pulse sequence is characterized with score 2 and 3 in benign changes, and 4 and 5 in malignant changes using the PI RADS score system for differentiation. T2W pulse sequence combined with diffusion is a powerful tool for non-invasive differentiation of benign prostatic hyperplastic nodule and prostatitis from a malignant nodule.

Keywords:prostate carcinoma, multiparametric MRI, T2Wpulse sequence,diffusion with ADC.

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