• Kristina Dimitrijevikj University Clinic of pulmology and alergology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Nadica Mitrevska Institute for Radiology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Sonja Nikolova Institute for Radiology, Faculty of Medicine, Ss Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Petar Janevski Institute for Radiology, Anatomy, Faculty of Medicine, Ss Cyril and Methodius University in Skopje, North Macedonia
  • Milkica Pashoska Institute of Radiology, Faculty of Medicine, Ss Cyril and Methodius University in Skopje, North Macedonia


Sarcoidosis is a multisystemic disease of unknown etiology that mostly affects the lung parenchyma with interstitial and granulomatous changes of varying intensity and expression depending on the stage of the disease. In addition to the parenchyma and interstitium, the mediastinal lymph nodes are also very often affected. To analyze the distribution and characteristics of interstitial lung lesions and the involvement of mediastinal lymph nodes in pulmonary sarcoidosis by the method of high-resolution computed tomography. 15 patients diagnosed with pulmonary sarcoidosis were included in the study. Computed tomography with high resolution was made on 128 slice CT scanner PHILIPS INCISIVE, using 1 mm thin-slice thickness and high spatial frequencies algorithm for image reconstruction. Lymph nodes are classified as hilar and mediastinal with a maximum diameter of short axis of more than 10 mm taken as their enlargement. Pulmonary changes are classified as nodules, reticular opacities, fibrous lesions, ground glass opacities and consolidations. The predominant distribution of lesions in the upper and middle zones of the lungs compared to the lower zones was noted. The disease is graded in 5 stages with the Scadding classification. 15 cases of patients diagnosed with sarcoidosis were analyzed all of whom are women in the age group of 30-60 years old. Two patient are in stage I and three are in III stage of the disease, 6 patients are in stage II of sarcoidosis and 4 are in stage IV of the disease. Dry cough as a symptom predominates in all patients, while dyspnea is graded according to the mMRC scale. Mediastinal lymphadenopathy with and without calcifications was present in 11 patients. The type of lung changes as well as their distribution are presented in graphs.HRCT is the method of choice in the evaluation of pathological changes in pulmonary sarcoidosis. It very precisely shows us the characteristic appearance of nodules and lesions, their distribution and atypical changes and helps us in grading the disease and its treatment.

Key words: lung, sarcoidosis, interstitial lung disease, HRCT.


1. Peeyush KD, Sarvinder S, Megha J, Satyendra NS, Rajat KS. Thoracic sarkoidosis: Imaging with High Resolution Computed tomography, 2017, original article, 1-4.
2. Criado E, Shanchez M, Ramirez J, Arguis P et al. Pulmonary Sarcoidosis :Manifestation of High Resolution CT with Pathologic Correlation, Chest Imaging, 2010, 1567- 1569.
3. Nunes H, Brillet PY, Valeyre D, Brauner MW,Wells AU. Imaging in sarcoidosis. Semin Respir Crit Care Med, 2007; 28: 102-120.
4. Keijsers RG, Veltkamp M, Grutters JC. Chest Imaging. Clin Chest Med 2015;36(4):603-619.
5. Webb WR, Higgins CB. Thoracic imaging, 2 nd Edition.philadelphia;Lippincott Williams andWilkins; 2011.
6. Silva M, Nunes H, Valeyre D, Sverzellati N.Imaging of sarcoidosis. Clin Rev Allergy Immunol. 2015;49(1): 45-53.
7. Wessendorf TE,Bonella F, Costabel U. Diagnosis of Sarcoidosis.Clin Rev Allergy Immunol. 2015;49(1): 54-62.
8. Reich JM. Mortality of intrathoracic sarcoidosis in referral vs population-based settings: influence of stage, ethnicity and corticosteroid therapy. Chest. 2002;121(1): 32-39.
9. Avital M, Halpern IH, Deeb M, Izbicki G. Radiological findings in sarcoidosis. IMAJ. 2008;10: 572-574.
10. Ortega IH, Gonzales LL. Update thoracic sarcoidosis. Radiologia. 2011;53(5): 443-448.
11. Al Jahdali, Rajiah P, Koteyar SS. Atipical Radiological manifestation of thoracic sarcoidosis: A rewiev and pictorial essay. Annals of Thoracic Medicine. 2013;8(4): 186-19.6
12. Malaisamy S, Dalal B, Bimenyuy C, Soubani AO. The clinical and radiologic features of nodular pulmonary sarcoidosis.Lung. 2009;187:9-15.
13. Davies CW, Tasker AD, Padley SP, Davies RJ, Gleeson FV. Air traping in sarcoidosis on computed tomography:Correlation with lung function. Clin Radiol. 2000;55(3):217-221.
14. Keijsers RG, Veltkamp M, Grutters JC. Chest imaging. Clin Chest Med 2015;36(4): 603-619.
15. Martin SG, Kronek LP, Valeyre D, Brauner N, Brillet PY, Nunes H, et al. High-resolution computed tomography to differentiate chronic diffuse interstitial lung diseases with predominant ground-glass pattern using logical analysis of data.eur Radiol.2010;20: 1297- 1310.
16. Armengol G, Bernet J, lahaxe L, Levesque H, Marie I. Uncommon manifestation revealing sarcoidosis.Rev Med Interne 2009;30:53-37.
How to Cite
DIMITRIJEVIKJ, Kristina et al. PULMONARY MANIFESTATION OF SARCOIDOSIS DETECTED ON HIGH RESOLUTION COMPUTED TOMOGRAPHY. Journal of Morphological Sciences, [S.l.], v. 6, n. 2, p. 59-65, nov. 2023. ISSN 2545-4706. Available at: <https://jms.mk/jms/article/view/vol6no2-7>. Date accessed: 28 nov. 2023.