COMPLICATED TUBERCULOSIS IN A 13 YEAR OLD CHILD WITH DOWN SYNDROME - A CASE REPORT

  • Hristijan Nestorov Institute for Respiratory Diseases in Children-Kozle, Skopje, North Macedonia
  • Katerina Boshkovska Institute for Respiratory Diseases in Children-Kozle, Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Filip Doksimovski Institute for Respiratory Diseases in Children-Kozle, Skopje, North Macedonia
  • Irena Chakalarovska Institute for Respiratory Diseases in Children-Kozle, Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Julija Ivanovska Institute for Respiratory Diseases in Children-Kozle, Skopje, North Macedonia
  • Zlatko Aleksovski University Clinic for Pediatric Surgery - Skopje, North Macedonia

Abstract

Tuberculosis (TB) is the most common cause of infectious disease-related mortality worldwide. Most persons infected won’t develop active disease, but in certain instances such as extremes of age or defects in cell-mediated immune response, TB may develop. Down syndrome (DS) is the most common neurodevelopmental disorder of know genetic cause and described simply as arising from an extra copy of chromosome 21, presenting with characteristic features. Due to immune defects, DS suffer more frequently from respiratory tract infections than normal children. We present a case of a 13 years old child with Down Syndrome who was diagnosed with lung tuberculosis, after a right sided lobectomy due to a lung abscess. The child was hospitalized, following a period of one and a half month with fever and vomiting that did not improve with therapy. Investigations were made, including CT scan on the lungs. Due to right sided empyema and abscess on the right upper lobe, right sided lobectomy was preformed. The postsurgical pathohistological findings were in addition to pulmonary tuberculosis. Four drug anti tuberculosis regimen was started.  The four-drug course was given for two months, and then a two-drug regime was continued. To this day the child is on the sixth month of the two-drug anti tuberculosis regime. CT scans, regular Chest X-rays and ultrasound of the lungs were made, with gradual improvement. In Down syndrome patients who have a complicated pneumonia that doesn’t respond to standard treatment, a tuberculosis disease should be considered.


Key words: child, down syndrome, tuberculosis.

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Published
2023-11-04
How to Cite
NESTOROV, Hristijan et al. COMPLICATED TUBERCULOSIS IN A 13 YEAR OLD CHILD WITH DOWN SYNDROME - A CASE REPORT. Journal of Morphological Sciences, [S.l.], v. 6, n. 2, p. 88-92, nov. 2023. ISSN 2545-4706. Available at: <https://jms.mk/jms/article/view/vol6no2-11>. Date accessed: 23 apr. 2024.
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Articles