TUBERCULOUS LYMPHADENITIS IN CHILDREN –14 YEARS OF EXPERIENCE

  • Katerina Boskovska Institute for Respiratory Diseases in Children- Kozle, Faculty of Medicine, Ss.Cyril and Methodius University in Skopje, North Macedonia
  • Julija Ivanovska Institute for respiratory diseases in children-Kozle, Skopje, North Macedonia
  • Hristijan Nestorov Institute for respiratory diseases in children-Kozle, Skopje, North Macedonia
  • Gorica Popova Institute for respiratory diseases in children-Kozle, Skopje, Faculty of Medicne, Goce Delcev University in Stip ,North Macedonia
  • Sandra Petlichkovska Institute for respiratory diseases in children-Kozle, Skopje, North Macedonia
  • Ivana Arnaudova - Danevska Institute for Respiratory Diseases in Children-Kozle, Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Irena Chakalarovska Institute for respiratory diseases in children-Kozle, Skopje, Faculty of Medicine , Ss. Cyril and Methodius University in Skopje, North Macedonia

Abstract

Tuberculosis (TB)is a major public health problem worldwide. It is one of the main causes of infectious disease and mortality, especially in developing countries. Extra pulmonary tuberculosis accounts for 15-20 % of all types of tuberculosis. Lymph nodes are the second most common localization after pleural TB. In childhood, the most commonly envolved  are the hilar lymph nodes. Material and methods: We analyzed the frequency of tuberculous lymphadenitis in children treated at the Institute for respiratory diseses in children-Kozle, in the last 14 years. From January 2006 to February 2020 , we’ve treated  397 children with  TB. 55 of them (13,8%), were with tuberculous lymphadenitis. Female children were 34 (61%), the others were   male.The most frequent was hilar lymphadenitis at 40 (72%), second  localization were cervical lymph nodes in 10( 18%). There was 1 child with submandibular localization,1 supraclavicular, 2children with axillary lymphadenitis and one with mesenterial lymphadenitis. Most of the patients had contact with TB. The diagnosis was confirmed pathohistological in the patients with peripheral lymphadenitis. Tuberculosis treatment was started in all patients based on clinical criteria, exposure, positive TST, chest X-ray, or histological confirmation. All of the patients have finished the treatment successfully.  Tuberculous lymphadenitis can be a diagnostic and therapeutic challenge in children. Early diagnosis and timely initiation of therapy lead to favorable therapeutic outcome and reduce complications.


Key words: tuberculosis, children,  lymphadentis.


 

References

1.World Health Organization. Global Tuberculosis Report 2022.
2.Raizada N, Khaparde SD, Salhotra VS, Rao R, Kalra A, Swaminathan S, et al. Accelerating access to quality TB care for pediatric TB cases through better diagnostic strategy in four major cities of India. PLoS One. 2018;13: e0193194.
3.Silva JB, Santos JC, Barbosa L, Carvalho I. Tuberculosis in the paediatric age group: a reflection on transmission. An Pediatr (Barc). 2021;94:403–11.
4.Perez-Velez CM, Marais BJ. Tuberculosis in children. N Engl J Med. 2012;367: 348–61.
5.Pai M, Schito M. Tuberculosis diagnostics in 2015: landscape, priorities, needs, and prospects. J Infect Dis. 2015;211 Suppl 2:S21–8.
6.Fontanilla JM, Barnes A, von Reyn CF. Current diagnosis and management of peripheral tuberculous lymphadenitis. Clin Infect Dis 2011;53:555.
7.Anunobi CC, Banjo AA, Abdulkareem FB, Daramola AO, Abudu EK. Review of the histopathologic patterns of superficial lymph node diseases, in Lagos (1991-2004). Niger Postgrad Med J. 2008;15:243–6.
8.Dandapat MC, Mishra BM, Dash SP, Kar PK: Peripheral lymph node tuberculous: a review of 80 cases. Br J Surg 1990, 77(8):911–912.
9.Mohapatra PR, Janmeja AK. Tuberculous Lymphadenitis. J Assoc Physicians India 2009; 57:585-90.
10.Gupta PR. Difficulties in managing lymph node tuberculosis. Lung India 2004;21:50.
11.Handa U, Mundi I, Mohan S. Nodal tuberculosis revisited: a review. J Infect Dev Ctries 2012; 6(1):6-12.
12.Kamal MS, Hoque MH, Chowdhury FR, et al. Cervical Tuberculous Lymphadenitis: Clinico-demographic Profiles of Patients in a Secondary Level Hospital of Bangladesh. Pak J Med Sci 2016; 32(3):608-12.
13.Chen YM, Lee PY, Su WJ, et al. Lymph node tuberculosis: 7-year experience in Veterans General hospital, Taipei, Taiwan. Tuber Lung Dis 1992; 73(6):368-71.
14.Wademan DT, Busakwe L, Nicholson TJ, Zalm M, Palmer M, Workman J, et al. Acceptability of a first-line anti-tuberculosis formulation for children: qualitative data from the SHINE trial. International Journal of Tuberculosis and Lung Disease 2019; 12:1263-8. [PMC free article] [PubMed] [Google Scholar].
Published
2023-11-04
How to Cite
BOSKOVSKA, Katerina et al. TUBERCULOUS LYMPHADENITIS IN CHILDREN –14 YEARS OF EXPERIENCE. Journal of Morphological Sciences, [S.l.], v. 6, n. 2, p. 82-87, nov. 2023. ISSN 2545-4706. Available at: <https://jms.mk/jms/article/view/vol6no2-10>. Date accessed: 21 dec. 2024.
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Articles