PROXIMAL RENAL TUBULES ENZYMURIA AS A SCREENING TEST IN PATIENTS WITH SERONEGATIVE SPONDYLOARTHROPATHIES

  • Dejan Spasovski University Clinic for Rheumatology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Emilija Sandevska University Clinic for Rheumatology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Svetlana Krstevska Balkanov PHI University Clinic for hematology –Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Ana Vaslievska University Clinic for Rheumatology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Ljindita Djemaili Jakupi University Clinic for Rheumatology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
  • Elena Cvetinovska General City Hospital ;8th September’’ – Skopje, North Macedonia
  • Kujtim Iseini General City Hospital -Tetovo’– Department of Internal Medicine, North Macedonia
  • Mediha Selimi PHI General Hospital Gostivar- Department of Internal Medicine, North Macedonia
  • Vladimir Mitreski PHI Institute of lung disease and tuberculosis, Faculty of Medicine, Ss.Cyril and Methodius University in Skopje, North Macedonia
  • Nikola Chamurovski PHI Institute of lung disease and tuberculosis, Faculty of Medicine, Ss.Cyril and Methodius University in Skopje, North Macedonia
  • Maja Jakimovska Dimitrovska University Institute of Radiology, Faculty of Medicine, Ss.Cyril and Methodius University in Skopje, Republic of North Macedonia

Abstract

The aims of this study are: to compare diagnostic values and laboratory variables of alanine aminopeptidase (microsomal AAP), γ-glutamyl transferase (γ-GT), β2-microglobulin (β2-M), C-Reactive Protein (CRP), and the index for disease activity (PASI) in the early diagnosis of previously untreated psoriatic arthritis (Psa) and to see how untreated psoriatic arthritis affected tubular function and the sensitivity of the brush border region, together with the diagnostic value of enzymes originating from the proximal renal tubules. From the standard methods of the International Federation for Clinical Chemistry (IFCC), we used the kinetic method for the determination of alanine aminopeptidase (microsomal AAP), γ-glutamyl transferase ((γ-G) and MEIA (Microparticles Enzyme Immunoassay (Abbott Axsym system)) for determination of β2microglobulin in the urine. We examined samples (serum and urine) from 70 participants (35 Psa untreated, 35 healthy control group). RF and CRP were determined with the latex agglutination test in the same participants. Of the 35 examined patients with Psa, 12 (34.28%) showed presence of APP enzymuria, 8 patients (22.85%) showed presence of γ-GT, and a low percentage (0% showed presence of β2-microglobulin in urine. AAP has a higher sensitivity thanγ-GT and β2-M in asymptomatic renal lesions in untreated Psa.


Keywords: alanine aminopeptidase (AAP),γ-GT (γ-glutamyl transferase),β2-microglobulin (β2-M), spondyloarthropathies.


https://doi.org/10.55302/JMS2361087s

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Published
2023-05-10
How to Cite
SPASOVSKI, Dejan et al. PROXIMAL RENAL TUBULES ENZYMURIA AS A SCREENING TEST IN PATIENTS WITH SERONEGATIVE SPONDYLOARTHROPATHIES. Journal of Morphological Sciences, [S.l.], v. 6, n. 1, p. 87-92, may 2023. ISSN 2545-4706. Available at: <https://jms.mk/jms/article/view/vol6no1-11>. Date accessed: 23 apr. 2024.
Section
Articles