CORELATION BETWEEN RHEUMATIC DISEASE AND AUTOHEMOLITIC ANEMIA

  • Dejan Spasovski 1University Clinic for Rheumatology Clinical Center Mother Therese, Skopje, Faculty of Medicine, Ss Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Emilija Sandevska University Clinic for Rheumatology Clinical Center Mother Therese, Skopje, Faculty of Medicine, Ss Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Svetlana Krsrevska Balkanov University Clinic of Hematology, Clinical Center Mother Therese, Skopje, Faculty of Medicine, Ss Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Aleksandra Pivkova Veljanovska University Clinic of Hematology, Clinical Center Mother Therese, Skopje, Faculty of Medicine, Ss Cyril and Methodius University in Skopje, Republic of North Macedonia

Abstract

The autoimmune hemolytic anemias antibody can be hot or cold, have an incidence of 70 to 80% may be idiopathic in 50 to 60% and the rest of the cases secondary to lymphoproliferative disorders, collagen disease, drugs, solid tumors, infections and inflammatory bowel disease. RA may result in the reduced lifespan of red blood cells. This could lead to anemia if the body is unable to produce new red blood cells at a sufficient rate. Understanding these links between RA and anemia is crucial. Anemia is a common comorbidity in individuals with rheumatoid arthritis (RA). In fact, anemia of the type characterized by low serum iron concentrations in conjunction with adequate iron stores is frequently associated with RA and has served as a model for anemia of chronic disease. Rheumatoid vasculitis can affect blood vessels in many parts of your body. For this reason, it can cause many different symptoms. It most often damages blood vessels to the skin, fingers and toes, nerves, eyes, and heart. This reduces blood flow to these areas and damages them. Rheumatoid arthritis (RA) may be associated with a range of extraarticular manifestations, with hematologic complications including anemia and other conditions with hematologic abnormalities, such as Felty syndrome and lymphoproliferative disorders, particularly lymphoma and large granular lymphocyte (LGL) leukemia


Keywords: rheumathic disease, autohemolitic anemia.

References

1. Batailler, ER; Klein, B; Durie, BGM. et al. Interrelationship between autoimmunity and B-lymphoid cell oncogenesis in humans. Clin. Exp. Rheumatol. 1989; 7:319-328.
2. Lechner, K; Obermeier, HL. Cancer-related microangiopathic hemolytic anemia: clinical and la¬bo¬¬ratory features in 168 reported cases. Medicine (Baltimore). 2012; 91:195-205.
3. Bernatsky, S; Ramsey-Goldman, R; Rajan, R. et al. Non-Hodgkin’s lymphoma in systemic lupus ery¬thematosus. Ann. Rheumatol. Dis. 2005; 64 :1507-1509.
4. Bernatsky, S; Ramsey-Goldman, R; Clarke, AE. Malignancy in systemic lupus erythematosus: what ha¬ve we learned ? Best Pract. Res. Clin. Rheumatol. 2009; 23 (4) :539-547.
5. Landgren, AM; Landgren, O; Gridley, G. et al. Autoimmune disease and subsequent risk of developing alimentary tract cancers among 4,5 million US male veterans. Cancer, 2011; 117 (6) :1163-1171.
6. Vaananen, P; Kaarianen, L. Fusion and hemolysis of erythrocytes caused by three togaviruses: Semliki Forest, Sindbis and Rubella. J. Gen. Virol. 1980; 46:467-475.
7. Huang, RT; Rott, R; Klenk, HD. Influenza viruses cause hemolysis and fusion of cells. Virology. 1981; 110:243-247.
8. Gogichadze, GK; Misabishvili, EV; Gogichadze, TG. Tumour cells formation by normal somtic cells’ fusion and cancer prevention prospects. Med. Hypotheses. 2006, 66, 1 :133- 136.
9. Gogichadze, GK; Gogichadze, TG. Karyogamic theory of cancer cell formation from the view of the XXI century. Nova Biomedical Books, New York. 2010.
10. Gogichadze, GK; Gogichadze, TG; Kamkamidze, GK. Presumably common trigger mechanism of action of diametrically different carcinogens on target cells. Cancer and Oncology Research. 2013; 1 (2), 65-68.
Published
2022-08-31
How to Cite
SPASOVSKI, Dejan et al. CORELATION BETWEEN RHEUMATIC DISEASE AND AUTOHEMOLITIC ANEMIA. Journal of Morphological Sciences, [S.l.], v. 5, n. 2, p. 76-78, aug. 2022. ISSN 2545-4706. Available at: <https://jms.mk/jms/article/view/vol5no2-12>. Date accessed: 25 sep. 2022.
Section
Articles