• Vesna Janevska Institute for Pathology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.of North Macedonia
  • Milan Samardziski University Clinic for Orthopaedic Diseases, TOARILUC, Clinical Center Mother Theresa, Ss. Cyril and Methodius University in Skopje, R. of North Macedonia
  • Rubens Jovanovic Institute for Pathology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.of North Macedonia
  • Dafina Nikolova University Clinic for Gastroenterohepathology, Ss. Cyril and Methodius University in Skopje, R. of North Macedonia
  • Stefan Pandilov University Clinic for Eye Diseases, Ss. Cyril and Methodius University in Skopje, R. of North Macedonia
  • Vlatko Karanfilovski University Clinic for Nephrology, Ss. Cyril and Methodius University in Skopje, R. of North Macedonia


This is an epidemiological study of bone metastasis (BM) diagnosed and treated in a period of 11 years. Age and sex distribution of BM, localization, origin of primary malignancy, plain radiography appearance, therapeutic options and survival of the patients were evaluated.  Of 86 patients, 52 were female and 34 male, ranging in age from 44 to 87 years.  The most common site of BM was femur, followed by spine and humerus, and the most common primary malignances were in the breast, lung, kidney and prostate, respectively. Almost one third of patients were with unknown primary malignancy at the time of BM diagnosis.The analysis of patients’ plain radiographies revealed that most BM were osteolytic lesions. Bisphosphonate therapy was applied in only 41.86% of patients, radiotherapy was applied in only 2.33% of patients and combination of bisphosphonates and radiotherapy received 8.14% of patients.The rest of the patients, 47.67%, were treated with symptomatic and/or with systemic therapy according to their primary malignancy.The survival analysis did not show statistically significant influence of any of the analyzed parameters in this study on the survival of the patients. Only 26.74% of patients survived 24 months and the high 73.26% survived 1 to 24 months.

Keywords: bone metastases, localization, primary malignancy, radiographic appearance, survival



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How to Cite
JANEVSKA, Vesna et al. DEMOGRAPHIC AND MORPHOLOGIC CHARACTERISTICS OF BONE METASTASES – 11 YEARS SINGLE CENTER EXPERIENCE. Journal of Morphological Sciences, [S.l.], v. 4, n. 1, p. 65-76, mar. 2021. ISSN 2545-4706. Available at: <>. Date accessed: 03 dec. 2022.