DIAGNOSTIC VALUES OF BIOCHEMICAL MARKERSIN ASPHYXED NEWBORNS WITH PROVEN SEPSIS

  • Aspazija Sofijanova PHI University Clinic for Children Diseases, Medical Faculty, University "Ss.Cyril and Methodius", Skopje, Republic of North Macedonia
  • Silvana Naunova Timovska PHI University Clinic for Children Diseases, Medical Faculty, University "Ss.Cyril and Methodius", Skopje, Republic of North Macedonia
  • Hristina Mangjukova PHI University Clinic for Children Diseases, Medical Faculty, University "Ss.Cyril and Methodius", Skopje, Republic of North Macedonia
  • Elizabeta Shuperliska PHI University Clinic for Children Diseases, Medical Faculty, University "Ss.Cyril and Methodius", Skopje, Republic of North Macedonia
  • Olivera Jordanova PHI University Clinic for Children Diseases, Medical Faculty, University "Ss.Cyril and Methodius", Skopje, Republic of North Macedonia
  • Sonja Bojadzieva PPHI University Clinic for Children Diseases, Medical Faculty, University "Ss.Cyril and Methodius", Skopje, Republic of North Macedonia

Abstract

Introduction: The aim of this study was to investigate the predictive values of biochemical parameters, including Procalcitonin (PCT), as an early diagnostic and prognostic marker for sepsis in asphyxed newborns with proven sepsis. Materials and Methods: This study was designed as a prospective study, where we included 110 (M:F=67:43) newborns with proven sepsis hospitalized in the Intensive Care Unit at the PHI University Children’s Hospital – Skopje.PCT and CRP,WBC one serum blood sample was obtained from each patient at the 24h at admission, as well asday 3 and day 7. Procalcitoninlevels were measured by using an immunoassay system Vidas, based on the Enzyme Linked Fluorescent Assay (ELFA) principles. Results: The newborns with proven sepsis have been divided into two groups. The first group included 50 proven septicpreterm newborns with a positive blood culture and the second group included 50 proven sepsis full-term newborns.We isolated forty two that had two or three bacteria at the same time. The identified bacteria included Staphylococcus aureus (n=56) mecA,Streptococcus  (n=6), Acinetobacter baumannii  (n=18), Serratia  marcescens (n=9) and Entrobacteriaceae (n=31), Candida albicans(n= 1), Candida parapsilosis(n=1).Statistical analysis confirmed significantly different values ​​of PCT in the analyzed time period in preterm newborns with proven sepsis p<0.001.Statistical analysis confirmed significantly different values ​​of PCT in the analyzed time period in newborns with proven sepsis with asphyxia p<0.001. Conclusion: The levels of PCT have important clinical significance in predicting the prognosis of asphyxed newborns with sepsis, to prevent the development of severe sepsis and septic shock.


Keywords:sepsis,C-reactive protein,procalcitonin PCT, asphyxed newborns

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Published
2020-07-03
How to Cite
SOFIJANOVA, Aspazija et al. DIAGNOSTIC VALUES OF BIOCHEMICAL MARKERSIN ASPHYXED NEWBORNS WITH PROVEN SEPSIS. Journal of Morphological Sciences, [S.l.], v. 3, n. 2, p. 3-12, july 2020. ISSN 2545-4706. Available at: <https://jms.mk/jms/article/view/126>. Date accessed: 21 dec. 2024.
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