THE ROLE OF MICROBIOME IN IMMUNE-MEDIATED UVEITIS

-literature review-

  • Stefan Pandilov PHI University Clinic for Eye Diseases, Skopje, North Macedonia
  • Icko Gjorgoski Faculty of Natural Sciences and Mathematics, Institute of Biology, "Ss. Cyril and Methodius", Skopje, North Macedonia
  • Natasha Trpevska Shekerinov PHI University Clinic for Eye Diseases,Faculty of Medicine, "Ss. Cyril and Methodius",University in Skopje, North Macedonia
  • Biljana Nikolovska PHI University Clinic for Eye Diseases, Skopje, North Macedonia
  • Ana Trpeska Boshkoska PHI University Clinic for Eye Diseases,Faculty of Medicine, "Ss. Cyril and Methodius" University in Skopje, North Macedonia
  • Marija Vezenkoska PHI University Clinic for Eye Diseases, Skopje, North Macedonia
  • Filip Guchev PHI University Clinic for Rheumatology,Faculty of Medicine, "Ss. Cyril and Methodius" University in Skopje, North Macedonia

Abstract

The microbiome has important physiological functions and is an essential element in the control of the immune response in the body. Its dysbiosis is today associated with the pathogenesis of a number of diseases, including non-infectious uveitis. These are immunologically mediated conditions, where disruption of autotolerance towards intraocular structures and immune mimicry are the basis of the pathophysiological mechanism. The aim of this paper is to present the current knowledge related to this complex interaction between the microbiome and intraocular homeostasis, as well as directions for possible therapeutic solutions through quantitative and qualitative modification of the microbiota. During the preparation of this literature review, a meta-analysis of data obtained from several large databases was approached: PubMed, Medline and EMBASE. Keywords such as: non-infectious uveitis, microbiome, intestinal microbiome, probiotics, immune-mediated diseases, human microbiota were used in the search. The obtained results were selected, processed and didactically arranged in order to present relevant current scientific views.


Keywords: non-infectious uveitis, microbiome, microbiota, dysbiosis, microbiome modulation.

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Published
2024-12-29
How to Cite
PANDILOV, Stefan et al. THE ROLE OF MICROBIOME IN IMMUNE-MEDIATED UVEITIS. Journal of Morphological Sciences, [S.l.], v. 7, n. 3, p. 35-46, dec. 2024. ISSN 2545-4706. Available at: <http://jms.mk/jms/article/view/vol7no3-5>. Date accessed: 26 mar. 2025.
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Vol 7 No 3 (2024): JMS
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