CHRONIC LYMPHOCYTIC LEUKEMIA ARISING IN PATIENT WITH HODGKIN LYMPHOMA TREATED WITH PERIPHERAL BLOOD STEM CELL TRANSPLANTATION -CASE REPORT

Sanja Trajkova; Aleksandra Pivkova-Veljanovska; Marija Popova-Labacevska; Martin Ivanovski; Svetlana Krstevska-Balkanov; Nevenka Ridova; Simona Stojanovska; Irina Panovska-Stavridis

Sanja Trajkova PHI University Clinic for hematology â€“Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
Aleksandra Pivkova-Veljanovska PHI University Clinic for hematology â€“Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
Marija Popova-Labacevska PHI University Clinic for hematology â€“Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
Martin Ivanovski PHI University Clinic for hematology â€“Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
Svetlana Krstevska-Balkanov PHI University Clinic for hematology â€“Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
Nevenka Ridova PHI University Clinic for hematology â€“Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
Simona Stojanovska PHI University Clinic for hematology â€“Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia
Irina Panovska-Stavridis PHI University Clinic for hematology â€“Skopje, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia

Abstract

Post-transplant lymphoproliferative disorders (PTLDs) are lymphoid or plasmacytic proliferations that develop as a consequence of immunosuppression in a recipient of a solid organ, bone marrow or stem cell allograft. The development of PTLDs is usually associated with Epstein-Barr virus (EBV) and the disorder is also termed EBV-associated lymphoproliferative disorder (LPD). The development of PTLD is a rare complication in autologous bone marrow/peripheral blood stem cell transplantation. In the present study, we report a case of LPD which developed following autologous peripheral blood stem cell transplantation for relapsing Hodgkin's lymphoma.

Keywords: CLL, post-transplant lymphoproliferative disorders, Covid 19.

References

1.Swerdlow SH, Webber SA, Chadburn A and Ferry JA: Posttransplant lymphoproliferative disorders. In: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Swerdlow SH, Campo E, Harris NL, et al (eds). IARC, Lyon, pp343-349, 2008).
2.Nash RA, Dansey R, Storek J, et al: Epstein-Barr virus associated post transplantation lymphoproliferative disorder after a high-dose of immunosuppressive therapy and autologous CD34-seletcted hematopoietic stem cell transplantation for severe autoimmune diseases. Biol Blood Marrow Transplant 9: 583-591, 2003.
3.Powell JL, Bunin NJ, Callahan C, Aplenc R, Griffin G and Grupp SA: An unexpectedly high incidence of Epstein-Barr virus lymphoproliferative disease after CD34+ selected autologous peripheral blood stem cell transplant in neuroblastoma. Bone Marrow Transplant 33: 651-657, 2004.
4.Stephens DM, et al. Hodgkin lymphoma arising in patients with chronic lymphocytic leukemia: outcomes from a large multi-center collaboration. Haematologica. 2021 106:2845-2852.
5.Bockorny B, Codreanu I, Dasanu CA.Hodgkin lymphoma as Richter transformation in chronic lymphocytic leukemia: A retrospective analysis of world literature. BrJ Haematol. 2012;156(1):50-66).
6.Hauke RJ, Greiner TC, Smir BN, Vose JM, Tarantolo SR, Bashir RM, Bierman PJ. Epstein-Barr virus-associated lymphoproliferative disorder after autologous bone marrow transplantation: report of two cases. Bone Marrow Transplant. 1998 Jun;21(12):1271-4.
7.List AF, Greco FA and Vogler LB: Lymphoproliferative diseases in immunocompromised hosts: the role of Epstein-Barr virus. J Clin Oncol. 1987;5: 1673-1689.
8.Izumiya S et al Epstein-Barr virus-associated lymphoproliferative disorder developed following autologous peripheral blood stem cell transplantation for relapsing Hodgkin's lymphoma. Oncol Lett. 2012 Jun;3(6):1203-1206.
9.Chatzikonstantinou T, COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study. Leukemia. 2021 Dec;35(12):3444-3454.