RARE CASE OF OVARIAN STEROID CELL TUMOR NOT OTHERWISE SPECIFIED IN A POSTMENOPAUSAL WOMAN

Iskra Bitoska; Toso Plaseski; Sasha Jovanovska Mishevska; Slavica Shubeska Stratrova; Biljana Todorova; Argjent Muca; Elizabeta Stojovska Jovanovska; Brankica Krstevska

Iskra Bitoska University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Faculty of Medicine, Ss.Cyril and Methodius University in Skopje, Republic of North Macedonia
Toso Plaseski University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Faculty of Medicine, Ss.Cyril and Methodius University in Skopje, Republic of North Macedonia
Sasha Jovanovska Mishevska University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Faculty of Medicine, Ss.Cyril and Methodius University in Skopje, Republic of North Macedonia
Slavica Shubeska Stratrova University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Faculty of Medicine, Ss.Cyril and Methodius University in Skopje, Republic of North Macedonia
Biljana Todorova University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Faculty of Medicine, Ss.Cyril and Methodius University in Skopje, Republic of North Macedonia
Argjent Muca University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Faculty of Medicine, Ss.Cyril and Methodius University in Skopje, Republic of North Macedonia
Elizabeta Stojovska Jovanovska University Institute of Radiology, Faculty of Medicine, Ss.Cyril and Methodius University in Skopje, Republic of North Macedonia
Brankica Krstevska University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Faculty of Medicine, Ss.Cyril and Methodius University in Skopje, Republic of North Macedonia

Abstract

Ovarian steroid cell tumors, not otherwise specified (NOS), are rare ovarian sex cordâ€“stromal tumors with malignant potential. They represent less than 0.1% of all ovarian neoplasms. Little is known about this tumor, it is rare, and only a small number of case reports are available in the literature. This type of tumor can produce testosterone, leading to hyperandrogenism, virilization and amenorrhea. Postmenopausal occurrences are rare. We present a 60-year-old woman with onset of virilization, worsening alopecia and excessive growth of hair on abdominal and genital parts of the body. She has elevated levels of adrenal androgens. Radiologic studies were consistent with left sided ovarian changes. A diagnostic and therapeutic bilateral salpingo-oophorectomy confirmed steroid cell tumor NOS in both ovaries. Post-operatively, the patient had complete resolution of her symptoms and normalization of testosterone levels.

Keywords: ovarian steroid cell tumor, ovarian neoplasma, hyperandrogenism, virilization.

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