OVERLAP SYNDROME IN A REFRACTORY CASE

Filip Guchev; Snezana Mishevska Perchinkova; Georgi Bozhinovski; Ljubinka Damjanovska

Filip Guchev University Clinic of Rheumatology, Faculty of Medicine, Ss Cyril and Methodius University in Skopje, R.North Macedonia
Snezana Mishevska Perchinkova University Clinic of Rheumatology, Faculty of Medicine, Ss Cyril and Methodius University in Skopje, R. North Macedonia
Georgi Bozhinovski University Clinic of Rheumatology, Faculty of Medicine, Ss Cyril and Methodius University in Skopje, R. North Macedonia
Ljubinka Damjanovska University Clinic of Rheumatology, Faculty of Medicine, Ss Cyril and Methodius University in Skopje, R. North Macedonia

Abstract

This is a report of the case of a 23 years-old girl with refractory dermatomyositis, complications in her treatment and the unfortunate fatal end. Dermatomyositis can be a notoriously difficult disease to treat, and remission is often elusive or short-lived despite aggressive therapy. In the years after the diagnosis, many aggressive modalities of treatment were tried, including rituximab. The patient had frequent exacerbations of the myositis, needed aggressive therapy and developed many side effects associated with the treatment. Most common of these were infections. After suffering severe stress, she developed fever, was diagnosed with sepsis and despite exhaustive treatment at the intensive care unit she passed away.

Key words: dermatomyositis, refractory, immunosuppression, sepsis.

https://doi.org/10.55302/JMS2251093g

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