ASSOCIATION OF THE NUMBER OF COMPONENTS OF THE MEATBOLIC SYNDROME AND CAROTID ARTERY DISEASE
Metabolic syndrome (MetS) is a group of at least three of the following metabolic disorders: central obesity, elevated glycaemia, high serum triglycerides, low serum high-density lipoprotein (HDL), and high blood pressure. Carotid artery disease (CAD) involves changes in the arterial wall that cause thickening of the intima-media (IMT), narrowing, or complete obstruction of the carotid artery lumen. Objective:To determine the impact of the number of MetS components on CAD. This analytical unicenteric cross-sectional study included 80 subjects with MetS according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. CAD was diagnosed with the Esaote My Lab70 HVG device, with a linear probe (7.5 MHz), according to the Ultrasound consensus criteria for CAD of the Association of Radiologists (2002, San Francisco). 34 subjects (42.5%) had 4 components of MetS, 24 subjects (30%) had 3 components, 22 subjects (27.5%) had 5 components. Gender and age have no statistically significant effect on the influence of metabolic risk factor as components of MetS (p = 0.38, p = 0.72, respectively). CAD was diagnosed in 77 subjects (96.25%), in 21 subject (87.5%) with 3 components of MetS and in all subjects with 4 and 5 components of MetS.This statistically confirmed that subjects with a smaller number of MetS components significantly have less CAD (p = 0.026). The increase in the number of components and the synergistic effect of individual MetS components is significantly associated with CAD.
Keywords: metabolic syndrome, carotid artery disease
Retrieved 19 July 2021
2. Easton JD, Saver JL, Albers GW, Alberts MJ, Chaturvedi S, Feldmann E, et al. Definition and evaluation of
transient ischemic attack: a scientific statement for healthcare professionals from the American Heart
Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia;
Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the
Interdisciplinary Council on Peripheral Vascular Disease. The American Academy of Neurology affirms the
value of this statement as an educational tool for neurology. Stroke. 2009;40(6):2276-2293.
3. Bonora E. The metabolic syndrome and cardiovascular disease. Ann Med. 2006;38(1):64-80.
4. Grundy SM. Pre-diabetes, metabolic syndrome, and cardiovascular risk. J Am Coll Cardiol. 2012;59(7):635-
5. Mackey RH, Sutton-Tyrrell K, Vaitkevicius PV, Sakkinen PA, Lyles MF, Spurgeon HA et al. Correlates of aortic
stiffness in elderly individuals: A subgroup of the Cardiovascular Healtfi Study. Am J Hypertens 2002; 15: 16-
6. Havlik RJ, Brock D, Lohman K, Haskell W, Snell P, O'Toole M et al. Higli-density lipoprotein cholesterol and
vascular stiffness at baseline in the activity counseling trial. Am J Cardiol 2001; 87: 104-107.
7. Meigs JB. Epidemiology of the metabolic syndrome. Am J Manag Care 2002; 8: S283-S292.
8. Isomaa B, Almgren P, Tuomi T, Forsén B, Lahti K, Nissén M et al. Cardiovascular morbidity and mortality
associated with the metabolic syndrome. Diabetes Care 2001; 24: 683-689.
9. Alexander CM, Landsman PB, Teutsch SM, Haffner SM. NCEP-defined metabolic syndrome, diabetes, and
prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes. 2003;
10. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the
third National Health and Nutrition Examination survey. J Am Med Assoc. 2002;287(3):356-359.
11. Robbins SL, Kumar V, Cotran RS, Ellenson LH, Pirog EC. Robbins and Cotran pathologic basis of disease, 8th
ed. Philadelphia, USA: Saunders/Elsevier; 2010.
12. Grundy SM. Pre-diabetes, metabolic syndrome, and cardiovascular risk. J Am Coll Cardiol. 2012;59(7):635-
13. Van Popele NM, Westendorp IC, Bots ML, Reneman RS, Hoeks AP, Hofman A et al. Variables of the insulin
resistance syndrome are associated with reduced arterial distensibility in healthy non-diabetic middle-aged
women. Diabetologia. 2000;43:665-672.
14. Bonora E, Kiechl S, Willeit J, Oberhollenzer F, Egger G, Bonadonna RC et al. Carotid atherosclerosis and
coronary heart disease in the metabolic syndrome: prospective data from the Bruneck study. Diabetes Care.
15. Anand SS, Yi Q, Gerstein H, Lonn E, Jacobs R, Vuksan V et al. Relationship of metabolic syndrome and
fibrinolytic dysfunction to cardiovascular disease. Circulation. 2003; 108(4):420-425.
16. Scuteri A, Najjar SS, Muller DC, Andres R, Hougaku H, Metter JE et al. Metabolic syndrome amplifies the age-
associated increases in vascular thickness and stiffness. J Am Coll Cardi.ol 2004;43(8):1388-1395.
17. Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M et al. Cardiovascular morbidity and mortality
associated with the metabolic syndrome. Diabetes Care. 2001;24(4):683- 689.
18. Ninomiya JK, L’Italien G, Criqui MH, Whyte JL, Gamst A, Chen RS. Association of the metabolic syndrome with
history of myocardial infarction and stroke in the Third National Health and Nutrition Examination Survey.
Circulation 2004;109(1):42– 46.
19. Olijhoek JK, van der Graaf Y, Banga JD, Algra A, Rabelink TJ, Visseren FL. The metabolic syndrome is
associated with advanced vascular damage in patients with coronary heart disease, stroke, peripheral arterial
disease or abdominal aortic aneurysm. Eur Heart J. 2004; 25(4): 342–348.
20. Zhou PA, Zhang CH, Chen YR, Li D, Song DY, Liu HM et al. Association between Metabolic Syndrome and
Carotid Atherosclerosis: A Cross-sectional Study in Northern China. Biomed Environ Sci. 2019;32(12):914-921.
21. Kerimkulova AS, Lunegova OS, Mirrakhimov AE, Abilova SS, Nabiev MP, Neronova KV et al. Association
between the intima-media thickness of the extracranial carotid arteries and metabolic syndrome in ethnic
Kyrgyzs. BMC Cardiovasc Disord. 2018;18(1):199.
22. Kawamoto R, Tomita H, Oka Y, Kodama A, Kamitani A. Metabolic Syndrome Amplifies the LDL-Cholesterol
Associated Increases in Carotid Atherosclerosis. 2005; 44(12):1232-1238.